Result Statistics
Result statistics
| Number unique A-genes | 3 |
|---|---|
| Number unique B-genes | 2110 |
| Number unique A-B gene pairs | 2902 |
| Total number of interactions | 18850 |
Top Interactions
| A-argument | B-argument | count |
|---|---|---|
| BMP2 | RUNX2 | 558 |
| BMP2 | SMAD1 | 485 |
| BMP2 | SMAD5 | 407 |
| SMAD1 | TGFbeta | 333 |
| SMAD1 | BMP | 310 |
| SMAD1 | BMP4 | 293 |
| BMP2 | SMAD9 | 293 |
| BMP2 | ALP | 278 |
| SMAD1 | GDF2 | 266 |
| BMP2 | SP7 | 226 |
A-list mapping 3 0
| input | recognized symbol | mapping type |
|---|---|---|
| bmp1 | BMP1 | Orthology Cluster |
| bmp2 | BMP2 | Orthology Cluster |
| smad1 | SMAD1 | Orthology Cluster |
A-List Input Mapping
| input | recognized symbol | mapping type |
|---|---|---|
| bmp1 | BMP1 | Orthology Cluster |
| bmp2 | BMP2 | Orthology Cluster |
| smad1 | SMAD1 | Orthology Cluster |
A-List Input Mapping
| input | recognized symbol | mapping type |
|---|
Interaction Partner Distribution A-List (Pie)
Interaction Partner Distribution A-List (Bars)
Most Frequent Interactions
Interactions with Common Partners
Table View
| Gene A Symbol | Gene B Symbol | Gene A Gene ID | Gene B Gene ID | Relation Types | Factuality | Fulltext Match Source | Document ID | Context |
|---|---|---|---|---|---|---|---|---|
| Smad1 | Bmp2 | 17125 | 12156 | Phosphorylation, Positive_regulation | none | 22609204 | BMP-2 stimulation induced phosphorylation of Smad1/5/8 in a similar fashion in both siWnt5a-treated cells and control cells, suggesting that Wnt5a was dispensable for the phosphorylation of Smads by BMP-2. | |
| SMAD1 | BMP2 | 4086 | 650 | Positive_regulation | none | 28809431 | Bone morphogenetic protein-2-induced activation of the Smad1 protein ultimately results in JunB synthesis, the first transcriptional step in myoblast dedifferentiation. | |
| BMP2 | BMP4 | 650 | 652 | Regulation, Positive_regulation | none | 8788040 | In contrast, a RAR beta-selective retinoid had little effect on Bmp-2 induction but repressed Bmp-4. | |
| BMP2 | DLX5 | 650 | 1749 | Gene_expression, Positive_regulation | none | 16115867 | Our previous results indicate that Dlx5 mediates BMP-2-induced Runx2 expression and osteoblast differentiation (Lee, M. | |
| SMAD1 | FST | 540488 | 327681 | Phosphorylation, Negative_regulation | none | 31965149 | However, days 1-3 follistatin treatment reduced the abundance of phosphorylated SMAD1/5 in cultured embryos. | |
| BMP2 | NFkappaB | 650 | FPLX:NFkappaB | Negative_regulation, Positive_regulation | none | 16259979 | We therefore conclude that in osteosarcoma Saos2 cells, NFkappaB represses BMP/Smad signaling and BMP2-induced differentiation through Smad7. | |
| Bmp2 | Sox9 | 12156 | 20682 | Negative_regulation, Positive_regulation | none | 18506848 | SB203580, a specific inhibitor for p38 pathway, blocked BMP-2-induced chondrogenic differentiation as well as Sox9 expression and its transactivation of downstream genes. | |
| Bmp2 | Tnfsf11 | 12156 | 21943 | Gene_expression, Positive_regulation | none | 17967138 | A reporter assay was used to determine whether BMP2-induced RANKL production is through transcriptional regulation of the RANKL promoter and whether it is mediated by Runx2. | |
| BMP1 | Il1b | 649 | 16176 | Positive_regulation | none | 26515063 | IL-1β activated the bone morphogenetic protein (BMP) signaling pathway in hepatocytes and in mouse liver, as indicated by increased phosphorylation of small mothers against decapentaplegic proteins. | |
| BMP2 | RUNX2 | 650 | 860 | Positive_regulation | none | 20175453 | On the other hand, in mature osteoblasts the interaction of menin and the TGF-beta/Smad3 pathway counteracts the BMP-2/Smad1/5- and Runx2-induced transcriptional activities leading to inhibition of late stage osteoblast differentiation. |
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Maintenance Notice2024-09-05
GePI currently receives an index rebuild. Until this completes, the interaction database is not complete. GePI can be used but results might be incomplete. This will take 3 to 4 days.