GePI - Retrieval of molecular gene interactions from the scientific literature

Result Statistics

Result statistics

Number unique A-genes	3
Number unique B-genes	104
Number unique A-B gene pairs	111
Total number of interactions	156

Top Interactions

A-argument	B-argument	count
BMP2	RUNX2	7
BMP2	XBP1	5
BMP2	DDIT3	4
BMP2	ERN1	4
BMP2	CREB3L1	4
BMP2	IL6	3
SMAD1	GDF2	3
BMP2	FTO	3
BMP2	Mir20a	3
SMAD1	SMAD5	2

A-list mapping 3 0

input	recognized symbol	mapping type
bmp1	BMP1	Orthology Cluster
bmp2	BMP2	Orthology Cluster
smad1	SMAD1	Orthology Cluster

Table View

Gene A Symbol	Gene B Symbol	Gene A Gene ID	Gene B Gene ID	Relation Types	Factuality	Fulltext Match Source	Document ID	Context
Bmp2	Smad5	12156	17129	Phosphorylation, Positive_regulation		sentence	23376954	In addition, BMP-2 specifically induced phosphorylation of Smad1/5/8 proteins and protected adult cardiomyocytes from long-lasting hypoxia-induced cellular damage and oxidative stress without activation of the cardiodepressant transforming growth factor-β pathway.
BMP2	MIR378-1	100157103	100498703	Regulation		sentence	PMC9532862	Ssc-miR-199a-5p and ssc-miR-378 may regulate many miRNAs and mRNAs, including novel_circ_000898-ssc-miR-199a-5p-CAV1 and novel_circ_000898-ssc-miR-378-BMP2, which could mediate ER stress-induced apoptosis and inflammation and attenuate hypoxia-induced injury in ATII cells under hypoxic conditions ().
SMAD1	TRPM7	4086	54822	Phosphorylation, Regulation		sentence	PMC6515203	In mesenchymal stromal cells (MSCs), TRPM7 senses mechanical stimuli, such as intermittent fluid shear stress and membrane tension, and regulates Ca2+ influx and phosphorylation of signaling kinases, Smad1/5 and p38 MAPK, whereas TRPM7 knockdown decreases MSC proliferation and viability, and induces cell death [].
BMP2	TBX20	650	57057	Positive_regulation		sentence	36805334	We show here that ER stress upregulates Tbx20, which activates downstream bone morphogenetic protein 2 (Bmp2)-pSmad1/5/8 signaling to induce cardiomyocyte proliferation and limit apoptosis.
Smad1	Eng	17125	13805	Phosphorylation, Positive_regulation		sentence	PMC5940299	Interestingly, Endoglin profoundly increases EC SMAD1/5/8 phosphorylation through BMP9-mediated Alk1 activation, particularly under HSS (), and promotes EC migration against the flow ().
Bmp2	CREB	12156	FPLX:CREB	Positive_regulation		sentence	PMC3760886	An ER stress transducer and a member of the CREB/ATF family, OASIS, was induced by BMP2 and shown to play an important role in bone formation and fracture healing –.
Bmp2	Hspa5	12156	14828	Gene_expression, Positive_regulation		sentence	PMC4047903	The expression levels of the ER stress markers, BiP (IgH chain-binding protein), CHOP (C/EBP homologous protein) and EDEM (ER degradation- enhancingα-mannosidase-like protein), were upregulated by BMP2 stimulation.
BMP2	MICAL2	650	9645	Regulation		sentence	PMC8458439	Among these are the genes which regulate hypoxia and oxidative stress response (CYP1A1, EGLN3, EPAS1, MMP2, PRKCB, AJUBA, FOXO1, LOXL2, LOXL4, MICAL2, and MOXD1) and genes which regulate the response to toxic substances (HTR1D, DHRS2, BMP2, EPHX1, INMT, MAOB, and TLR2).
BMP2	LOXL2	650	4017	Regulation		sentence	PMC8458439	Among these are the genes which regulate hypoxia and oxidative stress response (CYP1A1, EGLN3, EPAS1, MMP2, PRKCB, AJUBA, FOXO1, LOXL2, LOXL4, MICAL2, and MOXD1) and genes which regulate the response to toxic substances (HTR1D, DHRS2, BMP2, EPHX1, INMT, MAOB, and TLR2).
BMP2	EPAS1	650	2034	Regulation		sentence	PMC8458439	Among these are the genes which regulate hypoxia and oxidative stress response (CYP1A1, EGLN3, EPAS1, MMP2, PRKCB, AJUBA, FOXO1, LOXL2, LOXL4, MICAL2, and MOXD1) and genes which regulate the response to toxic substances (HTR1D, DHRS2, BMP2, EPHX1, INMT, MAOB, and TLR2).

GePI currently receives an index rebuild. Until this completes, the interaction database is not complete. GePI can be used but results might be incomplete. This will take 3 to 4 days.