GePI - Retrieval of molecular gene interactions from the scientific literature

Result Statistics

Result statistics

Number unique A-genes	9
Number unique B-genes	3141
Number unique A-B gene pairs	4374
Total number of interactions	36109

Top Interactions

A-argument	B-argument	count
AMPK	STK11	1275
AMPK	MTOR	1176
AMPK	ULK1	1026
AMPK	SIRT1	950
AMPK	ADIPOQ	948
AMPK	PPARGC1A	812
AMPK	ATIC	630
AMPK	TP53	503
AMPK	AKT	484
AMPK	CAMKK2	427

A-list mapping 1 0

input	recognized symbol	mapping type
fplx:AMPK	AMPK	FamPlex Concept

Table View

Gene A Symbol	Gene B Symbol	Gene A Gene ID	Gene B Gene ID	Relation Types	Factuality	Fulltext Match Source	Document ID	Context
AMPK	LEP	FPLX:AMPK	3952	Negative_regulation, Positive_regulation		none	22327423	Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells.
AMPK	SHMT2	FPLX:AMPK	6472	Phosphorylation, Positive_regulation		none	31167694	Conclusion SHMT2 may induce autophagy by promoting AMPK phosphorylation and directly or indirectly inhibiting mTOR activity, thus leading to chemotherapy-induced apoptosis tolerance and resistance to chemotherapeutics.
AMPK	ATM	FPLX:AMPK	472	Positive_regulation		none	29405820	Neratinib and niraparib caused the ATM-dependent activation of AMPK which in turn was required to cause mTOR inactivation, ULK-1 activation and ATG13 phosphorylation.
AMPK	SAG	FPLX:AMPK	6295	Positive_regulation		none	25582777	Moreover, SAG induced a profound AMP-activated protein kinase (AMPK) activation, and then directly phosphorylated and activated the downstream autophagy initiator Ulk1, independent of the autophagy suppressor mammalian target of rapamycin (mTOR) complex 1.
AMPK	ATIC	FPLX:AMPK	471	Positive_regulation		none	20664053	AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
AMPK	STK11	FPLX:AMPK	6794	Positive_regulation		none	20615625	IR induced a robust phosphorylation and activation of AMPK in all tumor cells, independent of LKB1.
AMPK	nedd4l.S	FPLX:AMPK	399396	Negative_regulation, Positive_regulation		none	23221389	AMPK inhibits Kv1.5 presumably in part by activation of Nedd4- 2 with subsequent clearance of channel protein from the cell membrane.
AMPK	STK11	FPLX:AMPK	6794	Positive_regulation		none	26398719	LKB1 phosphorylates and activates AMP-activated protein kinase (AMPK), which negatively regulates cancer cell proliferation and metabolism.
AMPK	PRKAA1	FPLX:AMPK	5562	Phosphorylation, Negative_regulation		none	29089333	EPS stimulated AMPK and CaMKII phosphorylation, and EPS-stimulated GLUT4 translocation was reduced in part by small interfering (si)RNA-mediated AMPKα1/α2 knockdown, compound C, siRNA-mediated Ca2+/calmodulin-dependent protein kinase (CaMKII)δ knockdown, or CaMKII inhibitor KN93.
AMPK	BTN2A1	FPLX:AMPK	11120	Positive_regulation		none	37648854	This induction of both BTN3A and BTN2A1 during metabolic crises is dependent on AMP-activated protein kinase (AMPK).

GePI currently receives an index rebuild. Until this completes, the interaction database is not complete. GePI can be used but results might be incomplete. This will take 3 to 4 days.