Find Molecular Interactions in the Scientific Literature
This website is free and open to all users and there is no login requirement
Filter the results by organism
Add multiple IDs separated by commas
Filter the result by interaction type
Filter the result by minimal factuality of the interactions
Filter the result by keywords occurring in the context of interactions
Filter the result by keywords occurring in headings of sections and abstracts that contain interactions
Result Statistics
Interaction Partner Distribution A-List (Pie)
Interaction Partner Distribution A-List (Bars)
Most Frequent Interactions
Interactions with Common Partners
Table View
Gene A SymbolGene B SymbolGene A Gene IDGene B Gene IDRelation TypesFactualityFulltext Match SourceDocument IDContext
AKT Epo FPLX:AKT / HGNCG:1900 24335 Phosphorylation, Positive_regulation
   
none17508273
 EPO induced sustained phosphorylation of Akt and its substrate, GSK-3beta, reduced caspase-3 activities in PC12 cells.
AKT Mir221 HGNCG:1900 / FPLX:AKT 100314163 Positive_regulation
   
none27113449
 MiR-221 promotes IgE-mediated activation of mast cells degranulation by PI3K/Akt/PLCγ/Ca(2+) pathway.
AKT Mir221 FPLX:AKT / HGNCG:1900 100314163 Gene_expression, Regulation
   
none27113449
 The influence of miR-221 on expression of phospholipase C gamma (PLCγ1), p-PLCγ1, protein kinase B (Akt), phospho-Akt (p-Akt), inhibitor of kappa B (IκB-α), and phospho-IκB-α (p-IκB-α) were examined by Western blot, whereas free calcium ion (Ca(2+)) level was measured by flow cytometry and NF-κB expression was determined by EMSA.
AKT Mir221 FPLX:AKT / HGNCG:1900 100314163 Gene_expression, Regulation
   
none27113449
 The influence of miR-221 on expression of phospholipase C gamma (PLCγ1), p-PLCγ1, protein kinase B (Akt), phospho-Akt (p-Akt), inhibitor of kappa B (IκB-α), and phospho-IκB-α (p-IκB-α) were examined by Western blot, whereas free calcium ion (Ca(2+)) level was measured by flow cytometry and NF-κB expression was determined by EMSA.
AKT Epo FPLX:AKT / HGNCG:1900 13856 Positive_regulation
   
none29315561
 Erythropoietin stimulates the phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway, which regulates Faim2 expression.
AKT Epo FPLX:AKT / HGNCG:1900 13856 Positive_regulation
   
none29315561
 Erythropoietin stimulates the phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway, which regulates Faim2 expression.
AKT MIR29A HGNCG:1900 / FPLX:AKT 407021 Phosphorylation, Negative_regulation, Gene_expression
   
none23023935
 The phosphorylation of AKT/mTOR downstream of SPARC was inhibited in miR-29a-overexpressing HCC cells.
AKT Hmox1 HGNCG:1900 / FPLX:AKT 24451 Negative_regulation, Positive_regulation
   
none26424114
 The inhibition of MEK/ERK1/2 or PI3K/AKT activity by U0126 or wortmannin, but not the inhibition of phospholipase Cγ by U73122, prevented FGF9-induced γ-GCS and HO-1 upregulation, changes in cellular redox status, and neuroprotection against MPP(+) toxicity in primary cortical and dopaminergic neurons.
AKT MMP9 FPLX:AKT / HGNCG:1900 4318 Positive_regulation
   
none25784559
 Our results revealed that BDE-47 significantly triggered the metastasis of human neuroblastoma SH-SY5Y cells via upregulation of MMP-9 by the GPER/PI3K/Akt signal pathway.
AKT RAS HGNCG:1900 / FPLX:AKT HGNCG:389 / FPLX:RAS Positive_regulation
   
none20578891
 RET/PTC, Ras, and receptor tyrosine kinase could dually activate the PI3K/Akt and MAPK pathways.
This Web application uses a single cookie to remember session state information. This session state is not used for any tracking but is required for the site to provide the offered service. By using this Web site you consent to the storage of an anonymous session ID.