GePI - Retrieval of molecular gene interactions from the scientific literature

Result Statistics

Result statistics

Number unique A-genes	1
Number unique B-genes	6
Number unique A-B gene pairs	6
Total number of interactions	1305

Top Interactions

A-argument	B-argument	count
MTOR	AMPK	1176
MTOR	PRKAA2	59
MTOR	PRKAA1	51
MTOR	PRKAB1	16
MTOR	PRKAB2	2
MTOR	PRKAG1	1

A-list mapping 1 0

input	recognized symbol	mapping type
mtor	MTOR	Orthology Cluster

B-list mapping 1 0

input	recognized symbol	mapping type
ampk	AMPK	FamPlex Concept

Table View

Gene A Symbol	Gene B Symbol	Gene A Gene ID	Gene B Gene ID	Relation Types	Factuality	Fulltext Match Source	Document ID	Context
MTOR	PRKAA2	2475	5563	Regulation		none	19679549	Metformin, the most widely used drug in the treatment of type 2 diabetes, activates AMP kinase (AMPK), which negatively regulates mTOR.
MTOR	AMPK	2475	FPLX:AMPK	Regulation		none	19679549	Metformin, the most widely used drug in the treatment of type 2 diabetes, activates AMP kinase (AMPK), which negatively regulates mTOR.
MTOR	PRKAA1	2475	5562	Negative_regulation, Positive_regulation		none	25591762	High glucose-induced extracellular matrix accumulation and mTOR activation were significantly inhibited by the co-treatment of rAAV-AMPKα1(312) (encoding constitutively active AMPKα1) whereas activated by r-AAV-AMPKα1D157A (encoding dominant negative AMPKα1).
MTOR	AMPK	2475	FPLX:AMPK	Regulation		none	33714781	Besides, metformin inhibits cystic fibrosis transmembrane conductance regulator (CFTR)-mediated fluids secretion and the mammalian target of rapamycin (mTOR)-involved cyst formation negatively regulated by AMPK in autosomal dominant polycystic kidney disease (APDKD).
MTOR	AMPK	2475	FPLX:AMPK	Negative_regulation		none	32245619	Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.
MTOR	AMPK	2475	FPLX:AMPK	Regulation		none	PMC4880882	Metformin has been shown to alter AMPK, a protein kinase that directly and indirectly regulates mTOR signaling via phosphorylation of Raptor and TSC2, respectively.
MTOR	AMPK	2475	FPLX:AMPK	Positive_regulation		none	PMC8945547	In hypopharyngeal cancer cells, p-mTOR was reduced through activation of ERK and AMPK signaling pathways by metformin, resulting in cell cycle arrest, apoptosis and autophagy triggering [].
MTOR	AMPK	2475	FPLX:AMPK	Positive_regulation		none	PMC5386770	Interestingly, Jin et al. proposed that Twist1 depletion sensitized NSCLC cells to cisplatin by stimulating AMPK-induced mTOR inhibition and subsequent reduction in Mcl-1 protein [].
Mtor	AMPK	56718	FPLX:AMPK	Regulation		none	PMC9526660	In addition, the mTOR is negatively regulated by AMPK, of which expression is up-regulated with suppressed autophagy.
MTOR	AMPK	2475	FPLX:AMPK	Negative_regulation, Positive_regulation		none	PMC6690605	Moreover, it also enhanced the lumican expression transcriptionally, which indicated that hypoxia-induced mTOR activation was blocked by activated AMPK.

GePI currently receives an index rebuild. Until this completes, the interaction database is not complete. GePI can be used but results might be incomplete. This will take 3 to 4 days.