GePI - Retrieval of molecular gene interactions from the scientific literature

Result Statistics

Result statistics

Number unique A-genes	1
Number unique B-genes	6
Number unique A-B gene pairs	6
Total number of interactions	1305

Top Interactions

A-argument	B-argument	count
MTOR	AMPK	1176
MTOR	PRKAA2	59
MTOR	PRKAA1	51
MTOR	PRKAB1	16
MTOR	PRKAB2	2
MTOR	PRKAG1	1

A-list mapping 1 0

input	recognized symbol	mapping type
mtor	MTOR	Orthology Cluster

B-list mapping 1 0

input	recognized symbol	mapping type
ampk	AMPK	FamPlex Concept

Table View

Gene A Symbol	Gene B Symbol	Gene A Gene ID	Gene B Gene ID	Relation Types	Factuality	Fulltext Match Source	Document ID	Context
MTOR	AMPK	2475	FPLX:AMPK	Positive_regulation		none	PMC5439273	This activated kinase stimulates AMPK, which induces autophagy via mTORC1 inhibition (via phosphorylation of TSC2 and the regulatory-associated protein of mTOR, Raptor).
MTOR	AMPK	2475	FPLX:AMPK	Gene_expression, Regulation		none	PMC4323096	Hence, AMPK may negatively regulate protein synthesis through the inhibition of both mTOR and ribosome synthesis.
MTOR	AMPK	2475	FPLX:AMPK	Phosphorylation, Positive_regulation		none	PMC9818605	In addition, AMPK phosphorylation induces mTOR inhibition, leading to autophagy inhibition [].
Mtor	AMPK	56717	FPLX:AMPK	Positive_regulation		none	PMC10378789	The regulation of mitophagy in cardiac differentiation is influenced by nutrient-sensing pathways, such as Akt/mTOR, which is upregulated in high-nutrient states, and AMPK, which is upregulated during fasting.
MTOR	AMPK	2475	FPLX:AMPK	Negative_regulation, Positive_regulation		none	PMC6628046	In general, AMP-activated protein kinase (AMPK) inhibits the activation of the mammalian target of rapamycin (mTOR), which negatively regulates autophagy.
Mtor	AMPK	56717	FPLX:AMPK	Negative_regulation		none	PMC6882892	Our results highlight that high glucose could significantly attenuate the unexpected adverse effect of metformin-induced MSC apoptosis through AMPK-mediated mTOR suppression.
MTOR	AMPK	2475	FPLX:AMPK	Regulation		none	PMC11008232	High nutrient availability also impedes the otherwise negative regulation of rapamycin (mTOR) by AMP-activated protein kinase (AMPK).
MTOR	AMPK	2475	FPLX:AMPK	Negative_regulation, Positive_regulation		none	PMC8401266	Under conditions of nutrient sufficiency, active mTOR inhibits AMPK activation and phosphorylates ULK1 at the S758 site in humans (Ser757 in mouse) [].
MTOR	AMPK	100127359	FPLX:AMPK	Regulation		none	PMC6784137	A study showed that in PCV2-infected PK-15 cells, AMPK and extracellular signal-related kinase (ERK)1/2 negatively regulate the mTOR pathway by phosphorylating TSC2; therefore, PCV2 may induce autophagy via the AMPK/ERK/TSC2/mTOR signaling pathway [].
MTOR	AMPK	2475	FPLX:AMPK	Negative_regulation, Positive_regulation		none	PMC7990371	LKB1-dependent activation of AMPK can directly lead to the phosphorylation of the tumor suppressor tuberous sclerosis complex 2 (TSC2) and, thus, can inhibit mTOR activation, thereby exerting an antitumor effect [, ].

GePI currently receives an index rebuild. Until this completes, the interaction database is not complete. GePI can be used but results might be incomplete. This will take 3 to 4 days.